the e295k dna polymerase beta gastric cancer

The E295K DNA Polymerase Beta Gastric Cancer-Associated

The E295K DNA Polymerase Beta Gastric Cancer-Associated

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. (PMID:17526740 PMCID:PMC1952088) PMID:17526740 PMCID:PMC1952088sp.info Involvement of DNA polymerase beta overeion in the Jul 05, 2013 · The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation Mol. Cell. Biol. , 27 ( 2007 ) , pp. 5587 - 5596 View Record in Scopus Google Scholarsp.info Cellular Roles of DNA Polymerase Beta - Europe PMCThe E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol. sp.info Prostate-Cancer-Associated I260M Variant of DNA The E295K DNA Polymerase Beta Gastric Cancer-Associated Variant Interferes with Base Excision Repair and Induces Cellular Transformation. Molecular and Cellular Biology 2007 , 27 (15) , 5587-5596.


			DNA polymerase beta promoter mutations affect gene

DNA polymerase beta promoter mutations affect gene

Nov 03, 2012 · Lang T, Dalal S, Chikova A et al (2007) The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol 27(15):5587–5596. PubMed Article CAS Google Scholar 7.sp.info Joann B. Sweasy - PublicationsThe E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Molecular and Cellular Biology. 27:5587-96. PMID 17526740 DOI:10.1128/MCB.01883-06 :0.56:2007:Lin GC, Jaeger J, Sweasy JB. Loop II of DNA polymerase beta is important for polymerization activity and fidelity.sp.info The Pol β variant containing exon α is deficient in DNA Jul 09, 2019 · The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol 27, 5587–5596, https:sp.info Leu22Pro tumor-associated variant of DNA polymerase beta

  • IntroductionMaterials and MethodsResultsDiscussionAcknowledgementsIn a mammalian cellular environment, DNA is under a continuous threat of spontaneous or chemical induced damage. Most of the time the damage is repaired ( 1 ). One of the most important repair systems is base excision repair (BER). It is estimated that at least 20 000 lesions/cell/day are repaired by BER ( 2 , 3) suggesting that this system is important for maintaining genomic integrity. Aberrant BER is likely to be associated with human cancer. The BER pathway is important for maintaining genomic integrity. BER rRESEARCH COMMUNICATION Association of Two

    
			Figure 1 from An Atypical DNA Polymerase Beta

    Figure 1 from An Atypical DNA Polymerase Beta

    DOI:10.4172/1948-5956.1000191 Corpus ID:87280635. An Atypical DNA Polymerase Beta Overeed in Human Aml/Hl-60 Malignant Cells @article{Bukhvostov2013AnAD, title={An Atypical DNA Polymerase Beta Overeed in Human Aml/Hl-60 Malignant Cells}, author={A. Bukhvostov and O. A. Shatalov and A. P. Orlov and D. Kuznetsov}, journal={Journal of Cancer Science & sp.info Structures of dNTP Intermediate States during DNA Sep 06, 2012 · The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol. Cell. Biol. 2007; 27 :5587-5596 Crossrefsp.info RCSB PDB - 4R64:Binary complex crystal structure of E295K Aug 22, 2014 · As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from sp.info Free Full Text Journal Articles:Molecular and Cellular The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol. 2007 Aug;27(15):5587-96. Approximately 30% of human tumors examined for mutations in polymerase beta (pol beta) appear to e pol beta variant proteins (D. Starcevic, S. Dalal, and J. B

    
			DNA Polymerase Beta Germline Variant Confers Cellular

    DNA Polymerase Beta Germline Variant Confers Cellular

    Mar 01, 2017 · Resistance to cancer chemotherapies leads to deadly consequences, yet current research focuses only on the roles of somatically acquired mutations in this resistance. The mutational status of the germline is also likely to play a role in the way cells respond to chemotherapy. The carrier status for the POLB rs3136797 germline mutation encoding P242R DNA polymerase beta (Pol β) is sp.info Anna Chikova - Manager. Research and Development - Senior Research and Development Scientist with a demonstrated history of playing leadership role in the biotechnology industry. Experienced in Molecular Diagnostics, DNA Sequencing, Epidemiology sp.info Understanding the loss-of-function in a triple missense Human DNA polymerase (pol) β is essential for base excision repair. We previously reported a triple somatic mutant of pol β (p.P261L/T292A/I298T) found in an early onset prostate tumor. This mutation abolishes polymerase activity, and the wild-type allele was not present in the tumor, indicating a complete deficiency in pol β function.sp.info Genome Instability Caused by a Germline Mutation in the DNA polymerase ß (Polß) is recognized as an essential DNA repair protein [1], [2].Although the smallest of the human DNA polymerases [3], [4], this 335–amino-acid protein is the primary DNA polymerase in the base excision repair (BER) pathway [5].A majority of the 20,000 DNA lesions per day that each human cell is faced with are repaired by the BER pathway [6].

    
			DNA polymerases in the risk and prognosis of colorectal

    DNA polymerases in the risk and prognosis of colorectal

    Oct 24, 2019 · Polymerase beta (Polβ), encoded by POLB gene, is the main polymerase involved in the base excision repair (BER). Its activity is essential for DNA replication and maintenance but some variants of POLB have been associated with an increased risk of developing ovarian, bladder and breast cancer sp.info Bacterial DNA repair genes and their eukaryotic homologues Lang T, Dalal S, Chikova A, DiMaio D, Sweasy JB (2007) The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol 27:5587-5596. Leppard JB, Champoux JJ (2005) Human DNA topoisomerase I:relaxation, roles, and damage control. Chromosoma 114:75-85.sp.info

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